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Ipamorelin 10vials

30.00

Ipamorelin is a selective growth-hormone secretagogue that binds to the growth-hormone secretagogue receptor type 1a (GHS-R1a) without significant activity at ghrelin O-acyltransferase or other pituitary hormone receptors. In in vitro and preclinical rodent models, it’s employed to dissect growth-hormone axis dynamics and downstream anabolic, lipolytic, and osteoanabolic pathways.

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          Description

          All products on this site are for research and development, laboratory, or analytical use only; they are not for human consumption, medical, diagnostic, cosmetic, veterinary, or any other non-research application. The statements and products have not been evaluated by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. Honest Peptide is not a compounding pharmacy or chemical compounding facility as defined under section 503A of the Federal Food, Drug, and Cosmetic Act, nor an outsourcing facility as defined under section 503B.

           

          Amino Acid Sequence

          Aib–His–D-2Nal–D-3Phe–Lys–NH₂

          Molecular Formula

          C₃₆H₄₉N₉O₅

          Molecular Weight

          711.82 g/mol

          PubChem CID

          16041794

          CAS Number

          170851-70-4

          Vial Size

          3ml

          Contents

          Lyophilized powder, white/off-white color
           

          Mechanism of action

          GHS-R1a Agonism & GH Secretion

          Ipamorelin selectively activates GHS-R1a on somatotrophs, coupling via Gαq/11 to PLCβ → IP₃/DAG signaling, triggering Ca²⁺-dependent exocytosis of growth hormone—yielding pulsatile release without concomitant ACTH or cortisol secretion.

          Anabolic & Lipolytic Signaling

          Elevated GH induces hepatic IGF-1 production, which engages the IGF-1R/PI3K/Akt pathway in muscle and adipose tissue, promoting protein synthesis and adipocyte lipolysis.

          Osteoanabolic Effects

          GH/IGF-1 axis activation upregulates Runx2 and osterix in osteoblasts via JAK2/STAT5 signaling, enhancing bone matrix deposition and mineralization.
           

          Storage & handling

          Storage:

          Store the lyophilized vial in a cool, dry area protected from direct sunlight.